articleTop 1% cited
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
European Journal of Cancer · 2012 · Vol. 48(10) · pp. 1466–1475
Carsten Bokemeyer✉(University Medical Center Hamburg-Eppendorf)Eric Van Cutsem(Universitair Ziekenhuis Leuven)Philippe Rougier(Assistance Publique – Hôpitaux de Paris)Fortunato Ciardiello(University of Campania "Luigi Vanvitelli")S. Heeger(Merck (Germany))Michael Schlichting(Merck (Germany))Ilhan Celik(Merck (Germany))Claus‐Henning Köhne(Klinikum Oldenburg)
Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancerHepatocellular Carcinoma Treatment and PrognosisKRASCetuximabMedicineInternal medicineOncologyColorectal cancerHazard ratioChemotherapyCancerConfidence interval
MeSH terms
CetuximabAdultAgedAged, 80 and overAntibodies, MonoclonalAntineoplastic AgentsEuropeFemaleHumansMaleMiddle AgedMutationNeoplasm MetastasisGenes, rasColorectal Neoplasms
Funding
- Merck KGaA
Citations
593
FWCI
34.47
field-weighted impact
References
23
Percentile
100%
vs. same field & year
Citations per year
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References
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
British Journal of Cancer · 2007 · 733 citations
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
Annals of Oncology · 2007 · 824 citations
FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study
Journal of Clinical Oncology · 2003 · 2,904 citations
Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor <i>KRAS</i> and <i>BRAF</i> Mutation Status
Journal of Clinical Oncology · 2011 · 1,880 citations
<i>KRAS</i> Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer
Cancer Research · 2006 · 2,215 citations
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