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Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

Stroke · 2009 · Vol. 40(5) · pp. 1849–1857

Mathias Gelderblom✉(Texas Tech University)Frank Leypoldt(Texas Tech University)Karin Steinbach(Texas Tech University)D. Behrens(Texas Tech University)Chi‐un Choe(Texas Tech University)Dominic A. Siler(Texas Tech University)Thiruma V. Arumugam(Texas Tech University)Ellen Orthey(Texas Tech University)Christian Gerloff(Texas Tech University)Eva Tolosa(Texas Tech University)Tim Magnus(Texas Tech University)

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Abstract

This study provides a detailed analysis of the temporal dynamics of immune cell accumulation in a rodent stroke model. The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.

Neuroinflammation and Neurodegeneration Mechanisms Immune Response and Inflammation Immune cells in cancerMicrogliaCD80Immune systemMedicineCD8ImmunologyInflammationDownregulation and upregulationMajor histocompatibility complexInfiltration (HVAC)

MeSH terms

AnimalsAntigen-Presenting CellsDendritic CellsFlow CytometryImmunity, CellularImmunohistochemistryInflammationKiller Cells, NaturalKineticsLymphocytesMacrophagesMice, Inbred C57BLNeutrophilsReperfusion InjuryMicroglia

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Inflammatory Cytokines in Experimental and Human Stroke