review Open AccessTop 10% cited
Persistent oxidative stress in cancer
FEBS Letters · 1995 · Vol. 358(1) · pp. 1–3
Shinya Toyokuni✉(Kyoto University)Keisei Okamoto(Kyoto University)Junji Yodoi(Kyoto University)Hiroshi Hiai(Kyoto University)
Abstract
DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent normal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.
Glutathione Transferases and PolymorphismsDNA Repair MechanismsGenomics, phytochemicals, and oxidative stressOxidative stressCancerGenome instabilityMetastasisCancer researchCancer cellBiologyTranscription factorDNA damageOncology
MeSH terms
8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineDNA, NeoplasmHumansModels, BiologicalNeoplasmsReactive Oxygen SpeciesOxidative Stress
Funding
- National Institutes of Health
- National Cancer Institute
Citations
1,215
FWCI
6.49
field-weighted impact
References
33
Percentile
97%
vs. same field & year
Citations per year
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References
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
The EMBO Journal · 1991 · 3,814 citations
Free radicals, antioxidant enzymes, and carcinogenesis
Free Radical Biology and Medicine · 1990 · 1,068 citations
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