review Open AccessTop 1% cited

Macrophages and Therapeutic Resistance in Cancer

Cancer Cell · 2015 · Vol. 27(4) · pp. 462–472

Brian Ruffell✉(Oregon Health & Science University)Lisa M. Coussens

Immune cells in cancer Phagocytosis and Immune Regulation Chemokine receptors and signalingCancer researchResistance (ecology)CancerCancer cellBiologyMedicineGenetics

MeSH terms

AnimalsHumansImmunity, CellularImmunotherapyMacrophagesNeoplasm MetastasisNeoplasmsNeovascularization, PathologicModels, ImmunologicalDrug Resistance, NeoplasmMiceTumor Microenvironment

Funding

U.S. Department of Defense
National Institutes of Health

Citations

1,477

FWCI

42.34

field-weighted impact

References

133

Percentile

100%

vs. same field & year

Citations per year

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References

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Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

Cancer Research · 2004 · 1,179 citations

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Nature Medicine · 2013 · 2,418 citations

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

Cancer Research · 2014 · 1,264 citations

Myeloid-derived suppressor cells as regulators of the immune system

Nature reviews. Immunology · 2009 · 6,584 citations

High interstitial fluid pressure — an obstacle in cancer therapy

Nature reviews. Cancer · 2004 · 2,134 citations

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Nature reviews. Cancer · 2014 · 2,100 citations

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