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Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review

AIDS · 2006 · Vol. 20(17) · pp. 2165–2174

Todd T. Brown✉(Johns Hopkins University)Roula Qaqish(Abbott Fund)

Abstract

The prevalence of osteoporosis in HIV-infected individuals is more than three times greater compared with HIV-uninfected controls. ART-exposed and PI-exposed individuals had a higher prevalence of reduced BMD and osteoporosis compared with their respective controls. The influence of other disease and treatment variables on these estimates could not be determined.

HIV-related health complications and treatments Pharmacological Effects and Toxicity Studies Bone and Joint DiseasesMedicineOsteoporosisOsteopeniaOdds ratioInternal medicineMeta-analysisBone mineralConfidence interval

MeSH terms

AdultAgedBone Diseases, MetabolicCross-Sectional StudiesFemaleHumansMaleMiddle AgedProtease InhibitorsBone DensityHIV InfectionsAntiretroviral Therapy, Highly Active

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921

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Future challenges for clinical care of an ageing population infected with HIV: a modelling study