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Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

Arthritis & Rheumatism · 2003 · Vol. 48(10) · pp. 2741–2749

Solbritt Rantapää‐Dahlqvist✉(Umeå University)B.A.W. de Jong(Radboud University Nijmegen)Ewa Berglin(Umeå University)Göran Hallmans(Umeå University)Göran Wadell(Umeå University)Hans Stenlund(Umeå University)Ulf Sundin(Stockholm University College of Music Education)Walther J. van Venrooij(Radboud University Nijmegen)

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Abstract

Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years. The presence of anti-CCP and IgA-RF predicted the development of RA, with anti-CCP antibody having the highest predictive value. This indicates that citrullination and the production of anti-CCP and RF autoantibodies are early processes in RA.

Rheumatoid Arthritis Research and Therapies Systemic Lupus Erythematosus Research Monoclonal and Polyclonal Antibodies ResearchRheumatoid arthritisRheumatoid factorMedicineImmunologyAntibodyCyclic peptideImmunoglobulin APeptideImmunoglobulin GBiology

MeSH terms

AdultAgedArthritis, RheumatoidAutoantibodiesCitrullineFemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMiddle AgedPredictive Value of TestsRheumatoid FactorCohort Studies