article Open AccessTop 1% cited
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
Cell Metabolism · 2009 · Vol. 9(4) · pp. 327–338
Aparna Purushotham✉(National Institutes of Health)Thaddeus T. Schug(National Institutes of Health)Qing Xu(National Institute of Environmental Health Sciences)Sailesh Surapureddi(National Institutes of Health)Xiumei Guo(National Institute of Environmental Health Sciences)Xiaoling Li(National Institute of Environmental Health Sciences)
Sirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismEndoplasmic Reticulum Stress and DiseaseSteatosisSirtuin 1BiologyFatty liverEndocrinologyLipid metabolismInternal medicineHepatocyteInflammationEndoplasmic reticulum
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsDietary FatsEndoplasmic ReticulumFatty AcidsFatty LiverFeeding BehaviorHomeostasisInflammationLigandsOrgan SpecificityOxidation-ReductionProtein BindingTranscription FactorsSignal Transduction
Funding
- National Institutes of Health
- National Institute of Environmental Health Sciences
Citations
1,100
FWCI
29.09
field-weighted impact
References
69
Percentile
100%
vs. same field & year
Citations per year
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JAMA · 2004 · 4,487 citations
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
Molecular and Cellular Biology · 2000 · 1,175 citations
Obesity is associated with macrophage accumulation in adipose tissue
Journal of Clinical Investigation · 2003 · 8,580 citations
Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins
Biochemical and Biophysical Research Communications · 2000 · 1,387 citations
Inflammation, stress, and diabetes
Journal of Clinical Investigation · 2005 · 3,869 citations
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Journal of Clinical Investigation · 1999 · 1,632 citations
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