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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Bioorganic & Medicinal Chemistry Letters · 2008 · Vol. 18(3) · pp. 923–928

Jacques Yves Gauthier✉Nathalie Chauret(TransCanada (Canada))Wanda Cromlish(TransCanada (Canada))Sylvie Desmarais(TransCanada (Canada))Le T. Duong(United States Military Academy)Jean‐Pierre Falgueyret(TransCanada (Canada))Donald B. Kimmel(United States Military Academy)Sonia Lamontagne(TransCanada (Canada))Serge Léger(TransCanada (Canada))Tammy LeRiche(TransCanada (Canada))Chun Sing Li(TransCanada (Canada))Frédéric Massé(TransCanada (Canada))Daniel J. McKay(TransCanada (Canada))Deborah A. Nicoll‐Griffith(TransCanada (Canada))Renata M. Oballa(TransCanada (Canada))James T. PalmerM. David Percival(TransCanada (Canada))Denis Riendeau(TransCanada (Canada))Joël Robichaud(TransCanada (Canada))Gideon A. Rodan(United States Military Academy)Sevgi B. Rodan(United States Military Academy)Carmai Seto(TransCanada (Canada))Michel Thérien(TransCanada (Canada))Vouy-Linh Truong(TransCanada (Canada))Michael C. VenutiGregg Wesolowski(United States Military Academy)Robert N. Young(TransCanada (Canada))Robert Zamboni(TransCanada (Canada))W. Cameron Black(TransCanada (Canada))

View via DOI Publisher page

Cell Adhesion Molecules Research Protease and Inhibitor Mechanisms Bone Metabolism and DiseasesCathepsin KChemistryEnzyme inhibitorCathepsinIntracellularPharmacologyCathepsin LBiochemistryEnzymeIn vitro

MeSH terms

AnimalsAzepinesBiphenyl CompoundsCathepsinsCollagenDogsFibroblastsHumansModels, BiologicalSkinStructure-Activity RelationshipSulfonesMolecular StructureOsteoporosis, PostmenopausalCysteine Proteinase Inhibitors

Citations

470

FWCI

12.10

field-weighted impact

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99%

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