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Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Neuron · 2004 · Vol. 41(6) · pp. 849–857
Michael BandellGina M. StorySun Wook HwangVeena ViswanathSamer R. EidMatt PetrusTaryn J. EarleyArdem Patapoutian
Ion Channels and ReceptorsNeurobiology and Insect Physiology ResearchHerbal Medicine Research StudiesTransient receptor potential channelTRPM8TRPV1ChemistryCapsaicinMentholTRPVNoxious stimulusBradykininTRPC

MeSH terms

TRPA1 Cation ChannelAcroleinAnimalsBehavior, AnimalBradykininCell MembraneCold TemperatureDose-Response Relationship, DrugCricetinaeHumansIon ChannelsMembrane PotentialsNeurons, AfferentNociceptorsPain

Funding

  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • National Institute of Neurological Disorders and Stroke
Citations
1,799
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References
Kinin receptors in pain and inflammation
European Journal of Pharmacology · 2001 · 465 citations
Principles of neural science
Trends in Neurosciences · 1982 · 9,169 citations
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Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin · Scinovex