Epilepsies as Dynamical Diseases of Brain Systems: Basic Models of the Transition Between Normal and Epileptic Activity

Abstract

We present an overview of these basic models, based on neurophysiologic recordings combined with signal analysis and on simulations performed by using computational models of neuronal networks. We pay especial attention to recent model studies and to novel experimental results obtained while analyzing EEG features preceding limbic seizures and during intermittent photic stimulation that precedes the transition to paroxysmal epileptic activity.