article Open AccessTop 1% cited

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

BMC Cancer · 2012 · Vol. 12(1) · pp. 91–91

Alexandria Haslehurst✉(Queen's University)Madhuri Koti(Queen's University)Moyez DharseePaulo Nuin(Queen's University)Ken Evans(Queen's University)Joseph GeraciTimothy Childs(Queen's University)Jian ChenJieran LiJohanne I. Weberpals(Ottawa Hospital)Scott Davey(Queen's University)Jeremy A. Squire(Queen's University)Paul C. Park(Queen's University)Harriet Feilotter(Queen's University)

View via DOI Full-text PDF

Abstract

This work strongly suggests that genes associated with EMT may play a significant role in cisplatin resistance in ovarian cancer, therefore potentially leading to the development of predictive biomarkers of drug response or novel therapeutic strategies for overcoming drug resistance.

Cancer Cells and Metastasis Metastasis and carcinoma case studiesSlugEpithelial–mesenchymal transitionBiologyGene knockdownVimentinCancer researchTransdifferentiationGene expression profilingSnailTranscription factor

MeSH terms

Snail Family Transcription FactorsAntineoplastic AgentsCell MovementCisplatinFemaleHumansNeoplasm InvasivenessNeoplasm ProteinsOvarian NeoplasmsRNA, MessengerMass SpectrometryTranscription FactorsCohort StudiesDrug Resistance, NeoplasmGene Expression Profiling