reviewTop 1% cited
Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis
The American Journal of Gastroenterology · 2014 · Vol. 109(10) · pp. 1547–1561
Alexander C. Ford✉(St James's University Hospital)Eamonn M.M. Quigley(Methodist Hospital)Brian E. Lacy(Dartmouth–Hitchcock Medical Center)Anthony Lembo(Beth Israel Deaconess Medical Center)Yuri A. Saito(Mayo Clinic)Lawrence R. Schiller(Baylor University Medical Center)Edy Soffer(University of Southern California)Brennan Spiegel(VA Greater Los Angeles Healthcare System)Paul Moayyedi(McMaster University)
Abstract
Probiotics are effective treatments for IBS, although which individual species and strains are the most beneficial remains unclear. Further evidence is required before the role of prebiotics or synbiotics in IBS is known. The efficacy of all three therapies in CIC is also uncertain.
Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomaliesGastroesophageal reflux and treatmentsMedicineSynbioticsIrritable bowel syndromeInternal medicineBloatingFlatulencePlaceboGastroenterologyMeta-analysisRandomized controlled trial
MeSH terms
AdultConstipationHumansAbdominal PainTreatment OutcomeDietary SupplementsProbioticsIrritable Bowel SyndromePrebioticsSynbiotics
Funding
- American College of Gastroenterology
Citations
728
FWCI
50.49
field-weighted impact
References
77
Percentile
100%
vs. same field & year
Citations per year
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References
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Alimentary Pharmacology & Therapeutics · 2007 · 362 citations
Chronic constipation: a survey of the patient perspective
Alimentary Pharmacology & Therapeutics · 2007 · 616 citations
Clinical trial: the effects of a trans‐galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome
Alimentary Pharmacology & Therapeutics · 2008 · 538 citations
Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
The American Journal of Gastroenterology · 2006 · 788 citations
A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome
Alimentary Pharmacology & Therapeutics · 2003 · 466 citations
Prevalence of, and Risk Factors for, Chronic Idiopathic Constipation in the Community: Systematic Review and Meta-analysis
The American Journal of Gastroenterology · 2011 · 875 citations
Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
BMJ · 2011 · 7,148 citations
Measuring inconsistency in meta-analyses
BMJ · 2003 · 61,700 citations
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