article Open AccessTop 10% cited
Muscular exercise can cause highly pathological liver function tests in healthy men
British Journal of Clinical Pharmacology · 2007 · Vol. 65(2) · pp. 253–259
Jonas Pettersson✉(AstraZeneca (Brazil))Ulf Hindorf(AstraZeneca (Brazil))Paula Persson(Lund University)Thomas Bengtsson(Lund University)Ulf Malmqvist(AstraZeneca (Brazil))Viktoría Werkström(AstraZeneca (Brazil))Mats Ekelund(AstraZeneca (Sweden))
Abstract
The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice.
Drug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and TreatmentDrug Transport and Resistance MechanismsMedicineCreatine kinaseBilirubinLiver function testsLiver functionInternal medicineLactate dehydrogenaseAlkaline phosphataseMyoglobinEndocrinology
MeSH terms
AdolescentAdultAlanine TransaminaseAspartate AminotransferasesClinical Enzyme Testsgamma-GlutamyltransferaseHumansLiverLiver Function TestsMaleMiddle AgedTime FactorsWeight LiftingExerciseMuscle, Skeletal
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