article Open AccessTop 10% cited
Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
BMC Genomics · 2012 · Vol. 13(1) · pp. 357–357
Jasenka Guduric‐Fuchs✉(Queen's University Belfast)Anna O’Connor(Queen's University Belfast)Bailey Camp(Queen's University Belfast)Ciarán O’Neill(Queen's University Belfast)Reinhold J. Medina(Queen's University Belfast)David Simpson(Queen's University Belfast)
Abstract
The global expression data provided by deep sequencing confirms that specific miRNAs are enriched in EVs released by HEK293T cells. Observation of similar patterns in a range of cell types suggests that a common mechanism for selective miRNA export may exist.
Extracellular vesicles in diseaseMicroRNA in disease regulationRNA Research and SplicingmicroRNABiologyHEK 293 cellsCell biologyTransfectionSmall RNADeep sequencingMicrovesiclesExtracellular vesicleGene silencing
MeSH terms
Base SequenceCell LineEndocytosisGene Expression RegulationGenetic VectorsHumansMolecular Sequence DataRNA, MessengerTransfectionOligonucleotide Array Sequence AnalysisGene Expression ProfilingTransport VesiclesMicroRNAsEndothelial CellsHEK293 Cells
Funding
- University of Texas Health Science Center at Houston
- Science Foundation Ireland
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council
Citations
552
FWCI
6.71
field-weighted impact
References
59
Percentile
98%
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Citations per year
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Gynecologic Oncology · 2008 · 2,297 citations
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