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Mathematical model for studying genetic variation in terms of restriction endonucleases.
Proceedings of the National Academy of Sciences · 1979 · Vol. 76(10) · pp. 5269–5273
Abstract
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.
Evolution and Genetic DynamicsMitochondrial DNARestriction enzymeNucleotide diversityGeneticsBiologyNucleotideEvolutionary biologyPopulationPopulation geneticsComputational biology
MeSH terms
Base SequenceComputersDNA Restriction EnzymesDNA, MitochondrialMathematicsModels, BiologicalGenetic Variation
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References
Molecular Population Genetics and Evolution.
Evolution · 1976 · 1,655 citations
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