review Open AccessTop 1% cited

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

Diabetologia · 2012 · Vol. 55(10) · pp. 2565–2582

Kyle D. Copps✉Morris F. White(Howard Hughes Medical Institute)

Metabolism, Diabetes, and Cancer Protein Kinase Regulation and GTPase Signaling Pancreatic function and diabetesIRS1IRS2Insulin receptorInsulin resistanceInsulin receptor substrateEndocrinologyInternal medicineInsulinBiologyPhosphorylation

MeSH terms

AnimalsDiabetes MellitusHumansInsulin ResistanceMice, TransgenicPhosphorylationSerineThreonineSignal TransductionMice, KnockoutModels, AnimalMiceInsulin Receptor Substrate Proteins

Citations

973

FWCI

19.73

field-weighted impact

References

186

Percentile

100%

vs. same field & year

Citations per year

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References

Adipose tissue as an endocrine organ

Molecular and Cellular Endocrinology · 2009 · 1,538 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Developmental Cell · 2002 · 807 citations

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Cell Metabolism · 2008 · 940 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Diabetes · 1999 · 1,255 citations

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Diabetes · 2002 · 1,374 citations

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Cell Metabolism · 2009 · 3,105 citations

Phosphorylation of IRS proteins, insulin action, and insulin resistance

American Journal of Physiology-Endocrinology and Metabolism · 2008 · 577 citations

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

Diabetes Care · 2009 · 2,031 citations

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