review Open AccessTop 1% cited
Tyrosine phosphorylation: thirty years and counting
Current Opinion in Cell Biology · 2009 · Vol. 21(2) · pp. 140–146
Tony Hunter✉(Salk Institute for Biological Studies)
Protein Tyrosine PhosphatasesGlycosylation and Glycoproteins ResearchProtein Kinase Regulation and GTPase SignalingBiologyPhosphorylationTyrosine phosphorylationTyrosine kinaseReceptor tyrosine kinaseTyrosineSignal transductionProtein tyrosine phosphataseKinaseCell biology
MeSH terms
AnimalsHumansNeoplasmsPhosphorylationProtein-Tyrosine KinasesTyrosineSignal TransductionEvolution, MolecularProtein Kinase Inhibitors
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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
Cancer Cell · 2002 · 1,620 citations
The Protein Kinase Complement of the Human Genome
Science · 2002 · 8,071 citations
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New England Journal of Medicine · 2004 · 11,455 citations
The selectivity of protein kinase inhibitors: a further update
Biochemical Journal · 2007 · 2,500 citations
A quantitative analysis of kinase inhibitor selectivity
Nature Biotechnology · 2008 · 2,427 citations
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
Proceedings of the National Academy of Sciences · 2004 · 4,332 citations
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