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Intensive Insulin Therapy in Critically Ill Patients
New England Journal of Medicine · 2001 · Vol. 345(19) · pp. 1359–1367
Greet Van den Berghe✉(KU Leuven)Pieter WoutersFrank WeekersCharles VerwaestFrans BruyninckxMiet SchetzDirk VlasselaersPatrick FerdinandePeter LauwersRoger Bouillon(KU Leuven)
Abstract
Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care unit.
Hyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and ResearchSepsis Diagnosis and TreatmentMedicineCritically illInsulinInsulin resistanceIntensive care medicineDiabetes mellitusCritical illnessInternal medicineEndocrinology
MeSH terms
Blood GlucoseCritical CareFemaleHumansHypoglycemic AgentsInsulinIntensive Care UnitsLength of StayMaleMiddle AgedPostoperative CareProspective StudiesRespiration, ArtificialLogistic ModelsSurvival Analysis
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References
The Clinical Significance of Positive Blood Cultures in the 1990s: A Prospective Comprehensive Evaluation of the Microbiology, Epidemiology, and Outcome of Bacteremia and Fungemia in Adults
Clinical Infectious Diseases · 1997 · 1,214 citations
Discrete sequential boundaries for clinical trials
Biometrika · 1983 · 1,735 citations
Therapeutic intervention scoring system
Critical Care Medicine · 1974 · 1,215 citations
Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year
Journal of the American College of Cardiology · 1995 · 1,573 citations
APACHE II-A Severity of Disease Classification System
Critical Care Medicine · 1986 · 13,403 citations
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
The Lancet · 1998 · 19,985 citations
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
New England Journal of Medicine · 1993 · 24,605 citations
Discrete Sequential Boundaries for Clinical Trials
Biometrika · 1983 · 1,675 citations
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