article Open AccessTop 10% cited
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma
BMC Genomics · 2014 · Vol. 15(1) · pp. 190–190
John C. Castle✉(Johannes Gutenberg University Mainz)Martin Löewer(Johannes Gutenberg University Mainz)Sebastian Boegel(University Medical Center of the Johannes Gutenberg University Mainz)Jos de Graaf(University Medical Center of the Johannes Gutenberg University Mainz)Christian Bender(Johannes Gutenberg University Mainz)Arbel D. Tadmor(University Medical Center of the Johannes Gutenberg University Mainz)Valesca Boisguérin(University Medical Center of the Johannes Gutenberg University Mainz)Thomas Bukur(Johannes Gutenberg University Mainz)Patrick Sorn(Johannes Gutenberg University Mainz)Claudia Paret(University Medical Center of the Johannes Gutenberg University Mainz)Mustafa Diken(Johannes Gutenberg University Mainz)Sebastian Kreiter(Johannes Gutenberg University Mainz)Özlem Türeci(Johannes Gutenberg University Mainz)Uğur Şahin(BioNTech (Germany))
Abstract
CT26 cells share molecular features with aggressive, undifferentiated, refractory human colorectal carcinoma cells. As CT26 is one of the most extensively used syngeneic mouse tumor models, our data provide a map for the rationale design of mode-of-action studies for pre-clinical evaluation of targeted- and immunotherapies.
Immunotherapy and Immune ResponsesCancer Genomics and DiagnosticsCancer Immunotherapy and BiomarkersBiologyCancer researchKRASColorectal cancerMajor histocompatibility complexTranscriptomeCancerCarcinogenesisAntigenGenetics
MeSH terms
AnimalsAntigens, NeoplasmCarcinomaColonic NeoplasmsMice, Inbred BALB CProto-Oncogene Proteins p21(ras)Sequence Analysis, DNACyclin-Dependent Kinase Inhibitor p16Polymorphism, Single NucleotideCell Line, TumorMiceHigh-Throughput Nucleotide SequencingTranscriptome
Citations
381
FWCI
6.26
field-weighted impact
References
53
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97%
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