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ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

The Journal of Experimental Medicine · 1971 · Vol. 133(2) · pp. 275–288

Judah Folkman✉(Boston Children's Hospital)Ezio Merler(Boston Children's Hospital)Charles M. Abernathy(Boston Children's Hospital)Gretchen M. Williams(Boston Children's Hospital)

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Abstract

Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.

Angiogenesis and VEGF in Cancer Cancer and biochemical research Cancer Research and TreatmentsAngiogenesisBlockadeCancer researchBiologyCell biologyNeovascularizationVascular endothelial growth factor AVascular endothelial growth factorVEGF receptorsReceptor

MeSH terms

AnimalsBlood VesselsCapillariesCarcinoma 256, WalkerCarcinoma, HepatocellularHumansLiver NeoplasmsMelanomaMitosisNeoplasm TransplantationNeoplasmsWilms TumorNeuroblastomaProteinsRNA

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Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells