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A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
JAMA · 1995 · Vol. 274(13) · pp. 1049–1049
Carol J. Boushey✉(Northwest University)
Abstract
A 5-mumol/L tHcy increment elevates CAD risk by as much as cholesterol increases of 0.5 mmol/L (20 mg/dL). Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease. Clinical trials are urgently needed. Concerns about masking cobalamin deficiency by folic acid could be lessened by adding 1 mg of cobalamin to folic acid supplements.
Folate and B Vitamins ResearchEsophageal and GI PathologyPregnancy and preeclampsia studiesMedicineOdds ratioHomocysteineInternal medicineVascular diseaseRisk factorCoronary artery diseasePopulationCardiologyGastroenterology
MeSH terms
ArteriosclerosisCoronary DiseaseFemaleFolic AcidFood, FortifiedHomocysteineHumansMalePyridoxineRisk FactorsVitamin B 12Vitamin B 12 Deficiency
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References
Homocysteinemia due to folate deficiency
Metabolism · 1987 · 420 citations
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
Atherosclerosis · 1994 · 530 citations
Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment
Atherosclerosis · 1990 · 396 citations
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
Nature Genetics · 1995 · 5,697 citations
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