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Cellular processing of platinum anticancer drugs

Nature Reviews Drug Discovery · 2005 · Vol. 4(4) · pp. 307–320
Dong WangStephen J. Lippard
Metal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryChronic Myeloid Leukemia TreatmentsCisplatinOxaliplatinCarboplatinDNA damageCytotoxicityDNA repairDrugChemistryPharmacologyPlatinum

MeSH terms

AnimalsAntineoplastic AgentsCell SurvivalDNA DamageDNA RepairHumansOrganoplatinum CompoundsTumor Cells, CulturedMolecular StructureSignal TransductionApoptosis

Funding

  • National Cancer Institute
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