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Multipotent Mesenchymal Stem Cells with Immunosuppressive Activity Can Be Easily Isolated from Dental Pulp

Transplantation · 2005 · Vol. 80(6) · pp. 836–842

Laura Pierdomenico(University of Bologna)Laura Bonsi(University of Bologna)Mario CalvittiDamiano RondelliMario Arpinati(University of Bologna)Gabriella Chirumbolo(University of Bologna)Ennio BecchettiCosetta Marchionni(University of Bologna)Francesco Alviano(University of Bologna)Valentina Fossati(University of Bologna)N StaffolaniMichele Franchina(University of Bologna)Alberto Grossi(University of Bologna)Gian Paolo Bagnara✉(University of Bologna)

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Abstract

Dental pulp is an easily accessible and efficient source of MSCs, with different kinetics and differentiation potentialities from MSCs as isolated from the bone marrow. The rapid proliferative capacity together with the immunoregulatory characteristics of DP-MSCs may prompt future studies aimed at using these cells in the treatment or prevention of T-cell alloreactivity in hematopoietic or solid organ allogeneic transplantation.

Mesenchymal stem cell research Periodontal Regeneration and Treatments Oral health in cancer treatmentMesenchymal stem cellMultipotent Stem CellBone marrowHaematopoiesisIn vitroAdipogenesisChondrogenesisCell biologyChemistryImmunology

MeSH terms

AdultCell DifferentiationCell SeparationCells, CulturedDental PulpFemaleHumansImmune ToleranceMaleMiddle AgedT-LymphocytesCell LineageMultipotent Stem CellsCell ProliferationMesenchymal Stem Cells

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Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine