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Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort

Allergy · 2015 · Vol. 70(8) · pp. 963–972

A. A. Schoemaker(Emma Kinderziekenhuis)A. B. Sprikkelman(Emma Kinderziekenhuis)Kate Grimshaw✉(University of Southampton)Graham Roberts(University Hospital Southampton NHS Foundation Trust)Linus Grabenhenrich(Charité - Universitätsmedizin Berlin)Leonard S. Rosenfeld(Charité - Universitätsmedizin Berlin)Sandy Siegert(German Agency for Quality in Medicine)R. Dubakiene(Vilnius University)Odilija Rudzevičienė(Vilnius University)M. Reche(Temple Street Children's University Hospital)Ana Fiandor(Hospital Universitario La Paz)Nikolaos G. Papadopoulos(National and Kapodistrian University of Athens)A. Malamitsi‐Puchner(National and Kapodistrian University of Athens)Alessandro Fiocchi(Bambino Gesù Children's Hospital)Lamia Dahdah(Bambino Gesù Children's Hospital)Sigurveig Sigurdardottir(National University Hospital of Iceland)Michael Clausen(National University Hospital of Iceland)Anna Stańczyk-Przyłuska(Medical University of Lodz)Krzysztof Zeman(Medical University of Lodz)E. N. Clare Mills(Manchester Academic Health Science Centre)Doreen McBride(Charité - Universitätsmedizin Berlin)Thomas Keil(University of Würzburg)Kirsten Beyer(Charité - Universitätsmedizin Berlin)

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Abstract

This unique pan-European birth cohort study using the gold standard diagnostic procedure for food allergies confirmed challenge-proven CMA in <1% of children up to age 2. Affected infants without detectable specific antibodies to cow's milk were very likely to tolerate cow's milk one year after diagnosis, whereas only half of those with specific antibodies in serum 'outgrew' their disease so soon.

Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization Contact Dermatitis and AllergiesIncidence (geometry)MedicineNatural historyAllergyCow's milk allergyCohortPediatricsCohort studyCow milkEnvironmental health

MeSH terms

AllergensAnimalsCattleChildChild, PreschoolDouble-Blind MethodEuropeFemaleHumansImmunoglobulin EInfantMaleMilk ProteinsSeverity of Illness IndexSkin Tests