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Notch signaling: control of cell communication and cell fate

Development · 2004 · Vol. 131(5) · pp. 965–973

Eric C. Lai✉(University of California, Berkeley)

Abstract

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.

Developmental Biology and Gene Regulation Hedgehog Signaling Pathway Studies Epigenetics and DNA MethylationBiologyNotch signaling pathwaySignal transductionCell fate determinationCell biologyHes3 signaling axisCellNotch proteinsMechanism (biology)Cell signaling

MeSH terms

AnimalsCell CommunicationDrosophilaFeedbackHumansMembrane ProteinsModels, BiologicalMutationSignal TransductionBody PatterningDrosophila ProteinsReceptors, Notch

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