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Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

Biological Psychiatry · 2009 · Vol. 65(9) · pp. 760–769
Tania L. RothFarah D. LubinAdam J. FunkJ. David Sweatt
Neuroendocrine regulation and behaviorStress Responses and CortisolChild Abuse and TraumaEpigeneticsDNA methylationOffspringBrain-derived neurotrophic factorPsychologyNeurotrophic factorsPrefrontal cortexChild abuseNeuroscienceGene expression

MeSH terms

AnimalsAnimals, NewbornCytidineFemaleHippocampusInjections, IntraventricularMaleMaternal BehaviorStress, PsychologicalGene ExpressionPrefrontal CortexDNA MethylationBrain-Derived Neurotrophic FactorRats, Long-EvansModels, Animal
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References
Environmental epigenomics and disease susceptibility
Nature Reviews Genetics · 2007 · 2,486 citations
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Journal of Neuroscience Research · 2006 · 939 citations
DNA methylation: The nuts and bolts of repression
Journal of Cellular Physiology · 2007 · 676 citations
The neurobiological consequences of early stress and childhood maltreatment
Neuroscience & Biobehavioral Reviews · 2003 · 1,438 citations
A Neurotrophic Model for Stress-Related Mood Disorders
Biological Psychiatry · 2006 · 3,300 citations
A new mathematical model for relative quantification in real-time RT-PCR
Nucleic Acids Research · 2001 · 34,549 citations
DNA methylation landscapes: provocative insights from epigenomics
Nature Reviews Genetics · 2008 · 3,047 citations
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
The American Journal of Human Genetics · 2008 · 774 citations
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