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PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

Human Pathology · 2015 · Vol. 47(1) · pp. 52–63

Ashley Cimino‐Mathews✉Elizabeth D. Thompson(Johns Hopkins Hospital)Janis M. TaubeXiaobu Ye(Johns Hopkins Hospital)Lu Yao(Johns Hopkins Hospital)Alan K. Meeker(Johns Hopkins Hospital)Haiying Xu(Johns Hopkins Hospital)Rajni Sharma(Johns Hopkins Hospital)Kristen Lecksell(Johns Hopkins Hospital)Toby C. Cornish(Johns Hopkins Hospital)Nathan Cuka(Johns Hopkins Hospital)Pedram ArganiLeisha A. Emens✉

View via DOI Publisher page

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses Cancer Cells and MetastasisPD-L1Tumor microenvironmentFOXP3CD8Tumor-infiltrating lymphocytesImmune systemMedicineMetastatic breast cancerBreast cancerBreast carcinoma

MeSH terms

AdultAgedAged, 80 and overBreast NeoplasmsCarcinomaFemaleHumansImmunohistochemistryMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisBiomarkers, TumorT-Lymphocyte SubsetsLymphocytes, Tumor-InfiltratingLymphocyte Count

Citations

336

FWCI

12.79

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

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References

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The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer

Breast Cancer Research and Treatment · 2013 · 342 citations

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

Breast Cancer Research and Treatment · 2014 · 577 citations

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

Science Translational Medicine · 2012 · 2,123 citations

Molecular portraits of human breast tumours

Nature · 2000 · 16,173 citations

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

Clinical Cancer Research · 2004 · 2,652 citations

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy

Clinical Cancer Research · 2014 · 2,320 citations

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