article Open AccessTop 10% cited
MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
BMC Cancer · 2010 · Vol. 10(1) · pp. 367–367
Chunzhi Zhang✉(Tianjin Medical University General Hospital)Han Lei(Tianjin Medical University General Hospital)Anling Zhang(Tianjin Medical University General Hospital)Yan-Chao Fu(Tianjin Medical University General Hospital)Yue Xiao(Tianjin Medical University General Hospital)Guangxiu Wang(Tianjin Medical University General Hospital)Zhifan Jia(Tianjin Medical University General Hospital)Peiyu Pu(Tianjin Medical University General Hospital)Qingyu Zhang(Tianjin Medical University General Hospital)Kang Chunsheng(Tianjin Medical University General Hospital)
Abstract
These results demonstrate that miR-221 and miR-222 regulate radiosensitivity, and cell growth and invasion of SGC7901 cells, possibly via direct modulation of PTEN expression. Our study suggests that inhibition of miR-221 and miR-222 might form a novel therapeutic strategy for human gastric cancer.
MicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseasesPTENmicroRNAClonogenic assayBiologyCancer researchCell growthCell cycleTransfectionGene knockdownRadioresistance
MeSH terms
AnimalsCell AdhesionCell CycleCell MovementCells, CulturedFibroblastsGamma RaysHumansImmunoenzyme TechniquesKidneyRadiation ToleranceRNA, MessengerStomach NeoplasmsBlotting, NorthernBlotting, Western
Funding
- Fourth Military Medical University
- Tianjin Science and Technology Committee
- Program for New Century Excellent Talents in University
Citations
383
FWCI
12.42
field-weighted impact
References
60
Percentile
99%
vs. same field & year
Citations per year
References
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