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Towards a molecular understanding of microRNA-mediated gene silencing

Nature Reviews Genetics · 2015 · Vol. 16(7) · pp. 421–433
Stefanie JonasElisa Izaurralde
RNA Research and SplicingMicroRNA in disease regulationRNA Interference and Gene DeliveryArgonauteGene silencingBiologyPsychological repressionmicroRNARNA-induced silencing complexTrans-acting siRNACell biologyRNA interferenceMessenger RNA

MeSH terms

AnimalsHumansProtein BiosynthesisGene SilencingRNA StabilityMicroRNAs

Funding

  • Deutsche Forschungsgemeinschaft
  • Gottfried Wilhelm Leibniz Universität Hannover
  • Max-Planck-Gesellschaft
Citations
1,867
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83.16
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116
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References
Regulation of microRNA biogenesis
Nature Reviews Molecular Cell Biology · 2014 · 5,427 citations
The mechanism of eukaryotic translation initiation and principles of its regulation
Nature Reviews Molecular Cell Biology · 2010 · 2,770 citations
Most mammalian mRNAs are conserved targets of microRNAs
Genome Research · 2008 · 8,505 citations
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC
Nature Structural & Molecular Biology · 2012 · 1,036 citations
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