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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Nature · 1998 · Vol. 391(6669) · pp. 806–811

Andrew Fire✉(Carnegie Institution for Science)Siqun Xu(Carnegie Observatories)Mary K. Montgomery(Carnegie Observatories)Steven A. Kostas(Johns Hopkins Medicine)Samuel E. Driver(University of Massachusetts Chan Medical School)Craig C. Mello(University of Massachusetts Chan Medical School)

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CRISPR and Genetic Engineering Genetics, Aging, and Longevity in Model Organisms Pluripotent Stem Cells ResearchRNA interferenceRNACaenorhabditis elegansBiologyDNA-directed RNA interferenceEndogenyMessenger RNACell biologyRNA silencingInterference (communication)

MeSH terms

AnimalsCalmodulin-Binding ProteinsGene Expression RegulationMuscle ProteinsPhenotypeRNA, Double-StrandedHelminth ProteinsRNA, AntisenseCaenorhabditis elegansGenes, HelminthCaenorhabditis elegans Proteins

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