article Open AccessTop 1% cited
A clinically applicable molecular-based classification for endometrial cancers
British Journal of Cancer · 2015 · Vol. 113(2) · pp. 299–310
Aline Talhouk✉Melissa K. McConechySamuel LeungHector Li-ChangJanice S. Kwon(University of British Columbia)Nataliya MelnykWinnie YangJanine SenzNiki BoydAnthony N. KarnezisDavid G. HuntsmanC. Blake GilksJessica N. McAlpine(University of British Columbia)
Abstract
Molecular classification of ECs can be achieved using clinically applicable methods on formalin-fixed paraffin-embedded samples, and provides independent prognostic information beyond established risk factors. This pragmatic molecular classification tool has potential to be used routinely in guiding treatment for individuals with endometrial carcinoma and in stratifying cases in future clinical trials.
Endometrial and Cervical Cancer TreatmentsCancer-related molecular mechanisms researchCircular RNAs in diseasesOncologyInternal medicineEndometrial cancerSurvival analysisImmunohistochemistryBiologyBioinformaticsMedicineCancer
MeSH terms
Poly-ADP-Ribose Binding ProteinsAgedDNA Polymerase IIFemaleHumansMiddle AgedMutationRetrospective StudiesGenes, p53Endometrial NeoplasmsPTEN Phosphohydrolase
Funding
- BC Cancer Foundation
Citations
921
FWCI
32.11
field-weighted impact
References
45
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
Human Pathology · 2011 · 1,068 citations
Prospective assessment of lymphatic dissemination in endometrial cancer: A paradigm shift in surgical staging
Gynecologic Oncology · 2008 · 813 citations
Internal validation of predictive models
Journal of Clinical Epidemiology · 2001 · 2,572 citations
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies
PLoS Medicine · 2008 · 815 citations
A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study
Gynecologic Oncology · 2004 · 1,647 citations
Cancer statistics, 2015
CA A Cancer Journal for Clinicians · 2015 · 11,899 citations
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