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Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation
New England Journal of Medicine · 2001 · Vol. 345(7) · pp. 494–502
Salim Yusuf✉(Hamilton General Hospital)
Abstract
The antiplatelet agent clopidogrel has beneficial effects in patients with acute coronary syndromes without ST-segment elevation. However, the risk of major bleeding is increased among patients treated with clopidogrel.
Antiplatelet Therapy and Cardiovascular DiseasesAtrial Fibrillation Management and OutcomesAcute Myocardial Infarction ResearchMedicineClopidogrelAspirinPlaceboInternal medicineMyocardial infarctionRelative riskStroke (engine)Acute coronary syndromeConfidence interval
MeSH terms
ClopidogrelAcute DiseaseAgedAspirinCardiovascular DiseasesDrug Therapy, CombinationElectrocardiographyFemaleHemorrhageHumansMaleMiddle AgedPlatelet Aggregation InhibitorsRisk FactorsTiclopidine
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6,459
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16
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References
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New England Journal of Medicine · 2000 · 8,641 citations
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
The Lancet · 1996 · 6,493 citations
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