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Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

British Journal of Dermatology · 2010 · Vol. 164(4) · pp. 776–784
Jeong Hyeon LeeJung Woo ChoiYeon Soo Kim

Abstract

This pooled analysis shows that the incidences of BRAF and NRAS mutations in cutaneous melanomas differ according to histological type and tumour location based on the degree of sun exposure.

Cutaneous Melanoma Detection and ManagementMelanoma and MAPK PathwaysCancer Genomics and DiagnosticsNeuroblastoma RAS viral oncogene homologMelanomaMedicineMeta-analysisOdds ratioDermatologyMutationPathologyOncologyInternal medicine

MeSH terms

Age FactorsDNA Mutational AnalysisFemaleGene FrequencyHumansMaleMelanomaMutationGenes, rasSex FactorsSkin NeoplasmsOdds RatioProto-Oncogene Proteins B-raf
Citations
412
FWCI
13.17
field-weighted impact
References
59
Percentile
99%
vs. same field & year
Citations per year
References
Cancer Statistics, 2009
CA A Cancer Journal for Clinicians · 2009 · 9,714 citations
Mutations of the BRAF gene in human cancer
Nature · 2002 · 10,619 citations
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Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis · Scinovex